Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Association between timing of cervical excision procedure to minimally invasive hysterectomy and surgical complications. Gynecol Oncol 2017 Feb;144(2):294-298

Date

11/30/2016

Pubmed ID

27894753

DOI

10.1016/j.ygyno.2016.11.037

Abstract

OBJECTIVE: To determine if the time interval between excision procedure and definitive minimally invasive surgery (MIS) for cervical cancer impacts 30-day postoperative complications.

METHODS: A retrospective cohort of patients diagnosed with cervical cancer from January 2000 to July 2015 was evaluated. Patients who underwent a cervical excision procedure followed by definitive MIS within 90days were included. Early definitive surgery was defined as ≤6 weeks following excision procedure, while delayed was defined as 6weeks to 3months. The primary outcome was 30-day complications. Statistical analysis included descriptive statistics and modified Poission regression.

RESULTS: Overall, 138 patients met inclusion criteria. Of these, 33% (n=46) had early definitive surgery and 67% (n=92) had delayed definitive surgery. Median age was 42years (range 23-72years) and median BMI was 28kg/m2 (range 16-50kg/m2). Within demographic and surgical factors collected, only smoking status differed between groups with those in the delayed surgery group more likely to be non-smokers than those in the early surgery group (p=0.04). When adjusting for relevant demographic and surgical factors, patients in the early group were twice as likely to have 30-day complication (aRR 2.6, 95%CI 1.14-5.76, p=0.02). Evaluating only women who underwent a radical procedure, 30-day complications remained higher in the early surgery group (RR 2.56; 95%CI 1.22-5.38, p=0.01).

CONCLUSIONS: Performing definitive MIS for cervical cancer within 6weeks after cervical excision is associated with increased risk for 30-day complications. Providers should consider delaying definitive surgical procedures for at least 6weeks following excision to reduce surgical complications.

Author List

Sullivan SA, Clark LH, Staley AS, Tran AQ, Winn A, Kim KH

Author

Aaron Winn PhD Assistant Professor in the School of Pharmacy Administration department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Cervix Uteri
Female
Humans
Hysterectomy
Middle Aged
Minimally Invasive Surgical Procedures
Postoperative Complications
Time Factors
Uterine Cervical Neoplasms
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a