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The inositol 1,4,5-trisphosphate receptor (Itpr) gene family in Xenopus: identification of type 2 and type 3 inositol 1,4,5-trisphosphate receptor subtypes. Biochem J 2007 Jun 15;404(3):383-91

Date

03/07/2007

Pubmed ID

17338679

Pubmed Central ID

PMC1896291

DOI

10.1042/BJ20070101

Scopus ID

2-s2.0-34250782108   10 Citations

Abstract

Studies in the Xenopus model system have provided considerable insight into the developmental role of intracellular Ca2+ signals produced by activation of IP3Rs (inositol 1,4,5-trisphosphate receptors). However, unlike mammalian systems where three IP3R subtypes have been well characterized, our molecular understanding of the IP3Rs that underpin Ca2+ signalling during Xenopus embryogenesis relate solely to the original characterization of the 'Xenopus IP3R' cloned and purified from Xenopus laevis oocytes several years ago. In the present study, we have identified Xenopus type 2 and type 3 IP3Rs and report the full-length sequence, genomic architecture and developmental expression profile of these additional IP3R subtypes. In the light of the emerging genomic resources and opportunities for genetic manipulation in the diploid frog Xenopus tropicalis, these data will facilitate manipulations to resolve the contribution of IP3R diversity in Ca2+ signalling events observed during vertebrate development.

Author List

Zhang D, Boulware MJ, Pendleton MR, Nogi T, Marchant JS

Author

Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Amino Acid Sequence
Animals
Calcium
Calcium Signaling
Evolution, Molecular
Female
Humans
Inositol 1,4,5-Trisphosphate Receptors
Molecular Sequence Data
Phylogeny
Protein Isoforms
RNA, Messenger
Sequence Alignment
Sequence Homology, Amino Acid
Xenopus
jenkins-FCD Prod-482 91ad8a360b6da540234915ea01ff80e38bfdb40a