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Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists. Biochem J 1998 Sep 15;334 ( Pt 3)(Pt 3):505-9

Date

09/08/1998

Pubmed ID

9729454

Pubmed Central ID

PMC1219715

DOI

10.1042/bj3340505

Scopus ID

2-s2.0-0032530345 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

Elementary Ca2+ puffs form the basic building blocks of global Ins(1, 4,5)P3-evoked Ca2+ signals. In Xenopus oocytes, Ca2+ puffs evoked by the high-affinity agonist adenophostin were shorter and smaller than puffs evoked by Ins(1,4,5)P3 and the lower affinity analogue Ins(2,4, 5)P3. Agonist-specific mechanisms, therefore, play a role in shaping local Ca2+ release events, but termination of Ca2+ flux is not delimited simply by agonist dissociation.

Author List

Marchant JS, Parker I

Author

Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adenosine
Animals
Calcium Channels
Calcium Signaling
Cerebellum
Female
In Vitro Techniques
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Inositol Phosphates
Kinetics
Microscopy, Confocal
Oocytes
Rats
Receptors, Cytoplasmic and Nuclear
Xenopus laevis