Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation. J Leukoc Biol 2012 Nov;92(5):933-7
Date
06/26/2012Pubmed ID
22730545Pubmed Central ID
PMC3476242DOI
10.1189/jlb.1211635Scopus ID
2-s2.0-84868321319 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
It is clear that latent CMV can reactivate in immunocompetent individuals, but the mechanism triggering such reactivations remains unclear. Recent clinical data suggest that reactivation can be subverted by CMV-specific T-memory. We therefore monitored CMV-specific T cells in immunocompetent mice with latent mCMV after a known reactivation trigger (LPS). LPS induced transient systemic contraction of mCMV-specific CD8 memory that was followed by transcriptional reactivation. Subsequent recovery of mCMV-specific T cells coincided with resumption of latency. These data suggest that bacterial antigen encounters can induce transient T-memory contraction, allowing viral recrudescence in hosts latently infected with herpes family viruses.
Author List
Campbell J, Trgovcich J, Kincaid M, Zimmerman PD, Klenerman P, Sims S, Cook CHAuthor
Jonathan Edward Campbell MD Assistant Professor in the Orthopaedic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntigens, Bacterial
CD8-Positive T-Lymphocytes
Cytomegalovirus
Cytomegalovirus Infections
Female
Flow Cytometry
Immunologic Memory
Lipopolysaccharides
Mice
Mice, Inbred BALB C
Reverse Transcriptase Polymerase Chain Reaction
Virus Activation
Virus Latency
