Herpes Simplex Virus Esophagitis in Immunocompetent Children: A Harbinger of Eosinophilic Esophagitis? J Pediatr Gastroenterol Nutr 2018 Apr;66(4):609-613
Date
09/25/2017Pubmed ID
28937540DOI
10.1097/MPG.0000000000001748Scopus ID
2-s2.0-85044226710 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Herpes simplex virus (HSV) is a common cause of infectious esophagitis. The aim of this retrospective study is to identify comorbid and predisposing conditions and sequelae of HSV esophagitis in immunocompetent children. We reviewed 16 cases of HSV esophagitis diagnosed from January 1982 to March 2016. Five patients were immunosuppressed, 11 were immunocompetent and included in the study. Three (27%) had no other significant medical history. Five patients (45%) had repeat biopsies following their HSV infection, which showed eosinophilic infiltrate consistent with current diagnostic criteria of eosinophilic esophagitis (EoE), one of whom had known EoE. Environmental allergies and/or asthma were present in 4 of 5 of these patients. Among the immunocompetent patients, EoE was a comorbidity in almost half, although biopsies at the time of HSV esophagitis did not show diagnostic features of EoE. Clinical follow-up is therefore warranted for immunocompetent children presenting with HSV esophagitis, particularly those with atopic conditions.
Author List
Fritz J, Lerner D, Suchi MAuthors
Diana Lerner MD Associate Professor in the Pediatrics department at Medical College of WisconsinMariko Suchi MD, PhD Associate Professor in the Pathology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AdolescentChild
Child, Preschool
Esophagitis
Esophagoscopy
Esophagus
Female
Herpes Simplex
Humans
Immunocompetence
Male
Retrospective Studies
Risk Factors
Simplexvirus