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Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Cell 2008 Sep 19;134(6):1055-65

Date

09/23/2008

Pubmed ID

18805097

Pubmed Central ID

PMC2628487

DOI

10.1016/j.cell.2008.07.017

Scopus ID

2-s2.0-51749083057   224 Citations

Abstract

The different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (mok) mutants, in which the motor protein Dynactin-1 is disrupted, interkinetic nuclei migrate more rapidly and deeply to the basal side and more slowly to the apical side. We found that Notch signaling is predominantly activated on the apical side in both mutants and wild-type. Mutant progenitors are, thus, less exposed to Notch and exit the cell cycle prematurely. This leads to an overproduction of early-born retinal ganglion cells (RGCs) at the expense of later-born interneurons and glia. Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals.

Author List

Del Bene F, Wehman AM, Link BA, Baier H

Author

Brian A. Link PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Body Patterning
Cell Cycle
Cell Differentiation
Cell Nucleus
Dynactin Complex
Embryo, Nonmammalian
Gene Expression Regulation, Developmental
Microtubule-Associated Proteins
Mutation
Neuroepithelial Cells
Organogenesis
Receptors, Notch
Retina
Retinal Ganglion Cells
Stem Cells
Zebrafish
Zebrafish Proteins
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0