Medical College of Wisconsin
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Protein Structure Facilitates High-Resolution Immunological Mapping. Clin Vaccine Immunol 2017 Dec;24(12)

Date

10/20/2017

Pubmed ID

29046310

Pubmed Central ID

PMC5717179

DOI

10.1128/CVI.00275-17

Scopus ID

2-s2.0-85040041257 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Select agents (SA) pose unique challenges for licensing vaccines and therapies. In the case of toxin-mediated diseases, HHS assigns guidelines for SA use, oversees vaccine and therapy development, and approves animal models and approaches to identify mechanisms for toxin neutralization. In this commentary, we discuss next-generation vaccines and therapies against ricin toxin and botulinum toxin, which are regulated SA toxins that utilize structure-based approaches for countermeasures to guide rapid response to future biothreats.

Author List

Zuverink M, Barbieri JT

Author

Joseph T. Barbieri PhD Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Botulinum Toxins
Botulism
Crystallography, X-Ray
Humans
Models, Molecular
Poisoning
Protein Conformation
Ricin
Vaccines