Molecular control of axon growth: insights from comparative gene profiling and high-throughput screening. Int Rev Neurobiol 2012;105:39-70
Date
12/05/2012Pubmed ID
23206595DOI
10.1016/B978-0-12-398309-1.00004-4Scopus ID
2-s2.0-84872382378 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Axon regeneration in the mammalian adult central nervous system (CNS) is limited by an intrinsically low capacity for axon growth in many CNS neurons. In contrast, embryonic, peripheral, and many nonmammalian neurons are capable of successful regeneration. Numerous studies have compared mammalian CNS neurons to their counterparts in regenerating systems in an effort to identify candidate genes that control regenerative ability. This review summarizes work using this comparative strategy and examines our current understanding of gene function in axon growth, highlighting the emergence of genome-wide expression profiling and high-throughput screening strategies to identify novel regulators of axon growth.
Author List
Blackmore MGAuthor
Murray Blackmore PhD Assistant Professor in the School of Allied Health department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnimalsAxons
Gene Expression Profiling
High-Throughput Screening Assays
Humans
Nerve Regeneration
Peripheral Nervous System Diseases
