Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei. Neurosci Lett 2011 Jul 12;498(3):213-7
Date
05/24/2011Pubmed ID
21600959Pubmed Central ID
PMC3130612DOI
10.1016/j.neulet.2011.05.011Scopus ID
2-s2.0-79959298804 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Fenfluramine reduces hunger and promotes body weight loss by increasing central serotonin (5-HT) signaling. More recently, neuropeptides have been linked to the regulation of feeding behavior, metabolism and body weight. To examine possible interactions between 5-HT and neuropeptides in appetite control, fenfluramine (200 nmol/0.5 μl/side) was administered directly into the hypothalamic paraventricular nuclei (PVN) of male rats. Bilateral fenfluramine produced significant hypophagia and increased expression of PVN corticotropin releasing factor (CRF) mRNA and neuropeptide Y (NPY) mRNA in the arcuate nucleus within the first hour after drug administration. Fenfluramine's effects on feeding behavior and mRNA expression were blocked by PVN injections of a 5-HT(1-2) receptor antagonist, metergoline (15 nmol/0.5 μl/side). These data suggest that 5-HT neurons targeting hypothalamic paraventricular CRF neurons may participate in an appetite control circuit for reducing food intake.
Author List
Boisvert JP, Boschuetz TJ, Resch JM, Mueller CR, Choi SAuthor
Sujean Choi PhD in the School of Allied Health department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnimalsAppetite Regulation
Arcuate Nucleus of Hypothalamus
Corticotropin-Releasing Hormone
Drug Interactions
Feeding Behavior
Fenfluramine
Male
Metergoline
Microinjections
Neuropeptide Y
Paraventricular Hypothalamic Nucleus
RNA, Messenger
Rats
Rats, Sprague-Dawley
Serotonin
