Synthesis of 2-Acylphenol and Flavene Derivatives from the Ruthenium-Catalyzed Oxidative C-H Acylation of Phenols with Aldehydes. European J Org Chem 2015 Mar;2015(9):1899-1904
Date
07/15/2015Pubmed ID
26167129Pubmed Central ID
PMC4493914DOI
10.1002/ejoc.201403518Scopus ID
2-s2.0-84924370547 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
The cationic ruthenium hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4- has been found to be an effective catalyst for the oxidative C-H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C-H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts.
