Deaminative and decarboxylative catalytic alkylation of amino acids with ketones. Angew Chem Int Ed Engl 2013 Dec 16;52(51):13651-5
Date
11/01/2013Pubmed ID
24174407DOI
10.1002/anie.201307766Scopus ID
2-s2.0-84890457343 (requires institutional sign-in at Scopus site) 35 CitationsAbstract
It cuts two ways: The cationic [Ru-H] complex catalyzes selective coupling of α- and β-amino acids with ketones to form α-alkylated ketone products. The reaction involves CC and CN bond cleavage which result in regio- and stereoselective alkylation using amino acids. A broad substrate scope and high functional-group tolerance is demonstrated.
Author List
Kalutharage N, Yi CSAuthor
Chae Yi PhD Professor, Inorganic and Organometallic Chemistry, Homogeneous Catalysis in the Chemistry department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AlkylationAmino Acids
Catalysis
Deamination
Ketones
Ruthenium
Stereoisomerism
