Chelate-Assisted Oxidative Coupling Reaction of Arylamides and Unactivated Alkenes: Mechanistic Evidence for Vinyl C-H Bond Activation Promoted by an Electrophilic Ruthenium-Hydride Catalyst. Organometallics 2010 Oct 21;29(22):5748-5750
Date
02/24/2011Pubmed ID
21344062Pubmed Central ID
PMC3041965DOI
10.1021/om100764cScopus ID
2-s2.0-78649293177 (requires institutional sign-in at Scopus site) 80 CitationsAbstract
The cationic ruthenium-hydride complex [(η(6)-C(6)H(6))(PCy(3))(CO)RuH](+)BF(4) (-) was found to be a highly regioselective catalyst for the oxidative C-H coupling reaction of aryl-substituted amides and unactivated alkenes to give ortho-alkenylamide products. The kinetic and spectroscopic analyses support a mechanism involving a rapid vinyl C-H activation followed by a rate-limiting C-C bond formation steps.