Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis. Cell Rep 2017 Dec 05;21(10):2785-2795
Date
12/07/2017Pubmed ID
29212026Pubmed Central ID
PMC5749980DOI
10.1016/j.celrep.2017.11.020Scopus ID
2-s2.0-85038074957 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
Angiogenesis inhibitors are important for cancer therapy, but clinically approved anti-angiogenic agents have shown only modest efficacy and can compromise wound healing. This necessitates the development of novel anti-angiogenesis therapies. Here, we show significantly increased EGFL6 expression in tumor versus wound or normal endothelial cells. Using a series of in vitro and in vivo studies with orthotopic and genetically engineered mouse models, we demonstrate the mechanisms by which EGFL6 stimulates tumor angiogenesis. In contrast to its antagonistic effects on tumor angiogenesis, EGFL6 blockage did not affect normal wound healing. These findings have significant implications for development of anti-angiogenesis therapies.
Author List
Noh K, Mangala LS, Han HD, Zhang N, Pradeep S, Wu SY, Ma S, Mora E, Rupaimoole R, Jiang D, Wen Y, Shahzad MMK, Lyons Y, Cho M, Hu W, Nagaraja AS, Haemmerle M, Mak CSL, Chen X, Gharpure KM, Deng H, Xiong W, Kingsley CV, Liu J, Jennings N, Birrer MJ, Bouchard RR, Lopez-Berestein G, Coleman RL, An Z, Sood AKAuthor
Sunila Pradeep PhD Associate Professor in the Obstetrics and Gynecology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlotting, Western
Calcium-Binding Proteins
Cell Adhesion Molecules
Cell Line, Tumor
Cell Movement
Chitosan
Female
Glycoproteins
Humans
In Vitro Techniques
Integrins
Mice
Mice, Knockout
Nanoparticles
Neoplasm Proteins
Neovascularization, Pathologic
Peptides
Phosphatidylinositol 3-Kinases
Phosphorylation
Proto-Oncogene Proteins c-akt
Receptor, TIE-2
Twist-Related Protein 1
Wound Healing