Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Intrathoracic Fat Measurements Using Multidetector Computed Tomography (MDCT): Feasibility and Reproducibility. Tomography 2017 Mar;3(1):33-40

Date

06/20/2017

Pubmed ID

28626797

Pubmed Central ID

PMC5472382

DOI

10.18383/j.tom.2017.00103

Scopus ID

2-s2.0-85038110344   2 Citations

Abstract

Intrathoracic fat volume, more specifically, epicardial fat volume, is an emerging imaging biomarker of adverse cardiovascular events. The purpose of this work is to show the feasibility and reproducibility of intrathoracic fat volume measurement applied to contrast-enhanced multidetector computed tomography images. A retrospective cohort study of 62 subjects free of cardiovascular disease (55% females, age = 49 A? 11 years) conducted from 2008 to 2011 formed the study group. Intrathoracic fat volume was defined as all fat voxels measuring -50 to -250 Hounsfield Unit within the intrathoracic cavity from the level of the pulmonary artery bifurcation to the heart apex. The intrathoracic fat was separated into epicardial and extrapericardial fat by tracing the pericardium. The measurements were obtained by 2 readers and compared for interrater reproducibility. The fat volume measurements for the study group were 141 A? 72 cm3 for intrathoracic fat, 58 A? 27 cm3 for epicardial fat, and 84 A? 50 cm3 for extrapericardial fat. There was no statistically significant difference in intrathoracic fat volume measurements between the 2 readers, with correlation coefficients of 0.88 (P = .55) for intrathoracic fat volume and -0.12 (P = .33) for epicardial fat volume. Voxel-based measurement of intrathoracic fat, including the separation into epicardial and extrapericardial fat, is feasible and highly reproducible from multidetector computed tomography scans.

Author List

Stojanovska J, Ibrahim EH, Chughtai AR, Jackson EA, Gross BH, Jacobson JA, Tsodikov A, Daneshvar B, Long BD, Chenevert TL, Kazerooni EA

Author

El-Sayed H. Ibrahim PhD Associate Professor in the Radiology department at Medical College of Wisconsin