Lobular neoplasia: morphology and management. Arch Pathol Lab Med 2014 Oct;138(10):1344-9
Date
10/01/2014Pubmed ID
25268198DOI
10.5858/arpa.2014-0278-CCScopus ID
2-s2.0-84907612102 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
CONTEXT: Lobular neoplasia encompasses a spectrum of disease, including atypical lobular hyperplasia and lobular carcinoma in situ. Although classic forms of lobular neoplasia are predominantly heralded as a risk marker, the pleomorphic form of lobular carcinoma in situ is generally regarded as a more aggressive subtype and a possible cancer precursor, and thus is treated in a manner more similar to ductal carcinoma in situ than classic forms of lobular neoplasia.
OBJECTIVE: To focus on the morphologic spectrum of lobular neoplasia as highlighted by 3 cases and current management recommendations. Areas of diagnostic challenge and controversy are addressed.
DATA SOURCES: A review of the pertinent published literature and current national guidelines was conducted.
CONCLUSIONS: Correct classification of classic lobular neoplasia and pleomorphic lobular carcinoma in situ is critical because of differences in clinical management, with current treatment strategies focused on risk reduction for patients with classic lobular neoplasia and eradication of the lesion for those with pleomorphic lobular carcinoma in situ.
Author List
Jorns J, Sabel MS, Pang JCAuthor
Julie M. Jorns MD Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedBreast
Breast Neoplasms
Calcinosis
Carcinoma in Situ
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Combined Modality Therapy
Diagnosis, Differential
Female
Humans
Hyperplasia
Middle Aged
Neoplasm Invasiveness
Precancerous Conditions
Precision Medicine
