Faculty Collaboration Database

Dopamine modifies the balance of rod and cone inputs to horizontal cells of the Xenopus retina. Brain Res 1988 May 24;449(1-2):332-6

Date

05/24/1988

Pubmed ID

3293703

DOI

10.1016/0006-8993(88)91048-7

Scopus ID

2-s2.0-0023934261 (requires institutional sign-in at Scopus site)   104 Citations

Abstract

Dopamine (greater than or equal to 2 microM) increased the cone input and suppressed the rod input to axon-bearing horizontal cells of the Xenopus retina. Dopamine (10 microM) also depolarized the horizontal cell by about 9 mV. The D2-dopamine antagonists spiperone and metoclopramide had the opposite action to dopamine, whereas the D1-dopamine antagonist SCH 23390 was without effect. None of the agents tested modified the light-evoked responses of rods.

Author List

Witkovsky P, Stone S, Besharse JC

MESH terms used to index this publication - Major topics in bold

Animals
Benzazepines
Dopamine
Dopamine Antagonists
Evoked Potentials
Membrane Potentials
Metoclopramide
Photic Stimulation
Photoreceptor Cells
Retina
Retinal Ganglion Cells
Spiperone
Xenopus