Medical College of Wisconsin
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Dopamine modifies the balance of rod and cone inputs to horizontal cells of the Xenopus retina. Brain Res 1988 May 24;449(1-2):332-6

Date

05/24/1988

Pubmed ID

3293703

DOI

10.1016/0006-8993(88)91048-7

Scopus ID

2-s2.0-0023934261 (requires institutional sign-in at Scopus site)   104 Citations

Abstract

Dopamine (greater than or equal to 2 microM) increased the cone input and suppressed the rod input to axon-bearing horizontal cells of the Xenopus retina. Dopamine (10 microM) also depolarized the horizontal cell by about 9 mV. The D2-dopamine antagonists spiperone and metoclopramide had the opposite action to dopamine, whereas the D1-dopamine antagonist SCH 23390 was without effect. None of the agents tested modified the light-evoked responses of rods.

Author List

Witkovsky P, Stone S, Besharse JC

Author

Joseph C. Besharse PhD, MA Emeritus Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Benzazepines
Dopamine
Dopamine Antagonists
Evoked Potentials
Membrane Potentials
Metoclopramide
Photic Stimulation
Photoreceptor Cells
Retina
Retinal Ganglion Cells
Spiperone
Xenopus