Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Arginine vasopressin responses to hypoxia and hypercapnia in late-gestation fetal sheep. Am J Physiol 1991 Jun;260(6 Pt 2):R1077-81

Date

06/01/1991

Pubmed ID

2058735

DOI

10.1152/ajpregu.1991.260.6.R1077

Scopus ID

2-s2.0-0025776216   57 Citations

Abstract

The purpose of this study was to determine the interaction of hypoxia and hypercapnia in the control of arginine vasopressin (AVP) secretion in fetal sheep and to determine the role of the peripheral arterial chemoreceptors in that response. We measured the plasma AVP response to hypercapnia and/or hypoxia in catheterized intact or sinoaortic-denervated fetal sheep between 123 and 144 days of gestation. Ewes were exposed to the following inspired gases: two successive 30-min periods of normocapnic normoxia, 30 min of normocapnic normoxia followed by 30 min of normocapnic hypoxia, two successive 30-min periods of hypercapnic normoxia, or 30 min of hypercapnic normoxia followed by 30 min of hypercapnic hypoxia (i.e., asphyxia). Hypercapnia per se had no significant effect on fetal plasma AVP. Normocapnic hypoxia per se resulted in a significant increase in fetal plasma AVP. Although hypercapnia resulted in a significant acidemia, the decrease in arterial pH was more marked under hypoxic conditions. Hypercapnia/acidemia augmented the AVP response to hypoxia. Fetal sinoaortic denervation did not significantly attenuate any of the AVP responses. We conclude that hypercapnia augments the fetal AVP response to hypoxia and that the AVP response to neither normocapnic nor hypercapnic hypoxia is dependent on afferent information carried in the carotid sinus or aortic nerves.

Author List

Raff H, Kane CW, Wood CE

Author

Hershel Raff PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arginine Vasopressin
Blood Gas Analysis
Chemoreceptor Cells
Female
Hydrogen-Ion Concentration
Hypercapnia
Hypoxia
Pregnancy
Pregnancy, Animal
Sheep
jenkins-FCD Prod-484 8aa07fc50b7f6d102f3dda2f4c7056ff84294d1d