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[Mutation Induction in the Mouse and Human Germline]. Genetika 2016 Jan;52(1):24-36

Date

05/18/2016

Pubmed ID

27183790

Scopus ID

2-s2.0-84974662330 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

The review describes the effects of exposure to mutagens on mutation induction in human and mouse germlines. The results of studies that evaluated inductions of mutations in human families subjected to irradiation are presented and discussed. The effects of exposure to mutagens on mutation induction in the mouse germline are also considered. We analyze and discuss the recent data on the genome-wide effects of irradiation on mutation induction in the mouse germline obtained by next-generation sequencing and comparative genome hybridization.

Author List

Dubrova YE

Author

Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Comparative Genomic Hybridization
Genome
Germ Cells
High-Throughput Nucleotide Sequencing
Humans
Mice
Mutagens
Mutation
Radiation