Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

NICU management and outcomes of infants with trisomy 21 without major anomalies. J Perinatol 2018 08;38(8):1068-1073

Date

05/26/2018

Pubmed ID

29795453

Pubmed Central ID

PMC6335104

DOI

10.1038/s41372-018-0136-5

Scopus ID

2-s2.0-85047337785   6 Citations

Abstract

OBJECTIVE: To describe how trisomy 21 affects neonatal intensive care management and outcomes of full-term infants without congenital anomalies.

STUDY DESIGN: Retrospective cohort of full-term infants without anomalies with and without trisomy 21 admitted to Pediatrix NICUs from 2005 to 2012. We compared diagnoses, management, length of stay, and discharge outcomes.

RESULTS: In all, 4623 infants with trisomy 21 and 606‚ÄČ770 infants without trisomy 21 were identified. One-third of infants in the NICU with and without trisomy 21 were full term without major anomalies. Trisomy 21 infants had more respiratory distress, thrombocytopenia, feeding problems, and pulmonary hypertension. They received respiratory support for a longer period of time and had a longer length of stay.

CONCLUSION: One-third of infants with trisomy 21 admitted to the NICU are full term without major anomalies. Common diagnoses and greater respiratory needs place infants with trisomy 21 at risk for longer length of stay.

Author List

McAndrew S, Acharya K, Nghiem-Rao TH, Leuthner S, Clark R, Lagatta J

Authors

Krishna Kartikey Acharya MBBS Assistant Professor in the Pediatrics department at Medical College of Wisconsin
Joanne M. Lagatta MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Steven R. Leuthner MD Professor in the Pediatrics department at Medical College of Wisconsin
T Hang Nghiem-Rao MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Birth Weight
Down Syndrome
Feeding Behavior
Female
Humans
Hypertension, Pulmonary
Infant, Newborn
Intensive Care Units, Neonatal
Intensive Care, Neonatal
Length of Stay
Linear Models
Male
Multivariate Analysis
Respiratory Distress Syndrome, Newborn
Retrospective Studies
Thrombocytopenia
United States