Motor unit number estimation (MUNE): Where are we now? Clin Neurophysiol 2018 Aug;129(8):1507-1516
Date
05/29/2018Pubmed ID
29804042DOI
10.1016/j.clinph.2018.04.748Scopus ID
2-s2.0-85047271924 (requires institutional sign-in at Scopus site) 75 CitationsAbstract
Estimation of the number of motor units (MUNE) in specific muscles is important to monitor outcome in progressive neurogenic disorders, with potential application in clinical trials. However, in spite of recent developments to identify the most convenient technique for MUNE, all current methods have individual shortcomings. It is essential to understand the scientific concepts that support MUNE and the many methods already proposed. In particular, the core role of the compound muscle action potential (CMAP) size in the estimation process is undervalued. Operator-dependent variation in CMAP amplitude or area is the main factor underlying MUNE stability. At present, MUNIX, as standardized in many centers, is probably the best accepted method. Future developments should be based on full understanding of the neurophysiological concepts underlying the MUNE calculation, in order to find a quick, well-tolerated, operator-friendly and reliable method to apply more universally in clinical practice.
Author List
de Carvalho M, Barkhaus PE, Nandedkar SD, Swash MAuthor
Paul E. Barkhaus MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Action PotentialsAmyotrophic Lateral Sclerosis
Electromyography
Humans
Motor Neurons
Muscle, Skeletal
Recruitment, Neurophysiological
