Medical College of Wisconsin
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Epigenetics for the pediatric cardiologist. Congenit Heart Dis 2017 Dec;12(6):828-833

Date

10/07/2017

Pubmed ID

28984030

DOI

10.1111/chd.12543

Scopus ID

2-s2.0-85035746507 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

A genetic basis of congenital heart disease (CHD) has been known for decades. In addition to the sequence of the genome, the contribution of epigenetics to pediatric cardiology is increasingly recognized. Multiple epigenetic mechanisms, including DNA methylation, histone modification, and RNA-based regulation, are known mediators of cardiovascular disease, including both development and progression of CHD and its sequelae. Basic understanding of the concepts of epigenetics will be essential to all pediatric cardiologists in order to understand mechanisms of pathophysiology, pharmacotherapeutic concepts, and to understand the role of epigenetics in precision medicine.

Author List

Spearman AD

Author

Andrew Spearman MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cardiologists
Cardiovascular Diseases
Child
Clinical Competence
Epigenesis, Genetic
Humans