Focal adhesions, contractility, and signaling. Annu Rev Cell Dev Biol 1996;12:463-518
Date
01/01/1996Pubmed ID
8970735DOI
10.1146/annurev.cellbio.12.1.463Scopus ID
2-s2.0-0029731588 (requires institutional sign-in at Scopus site) 1735 CitationsAbstract
Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provided a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, in cells that are tightly adherent to the substrate, generates isometric tension. In turn, this leads to the bundling of actin filaments and the aggregation of integrins (extracellular matrix receptors) in the plane of the membrane. The aggregation of integrins activates the focal adhesion kinase and leads to the assembly of a multicomponent signaling complex.
Author List
Burridge K, Chrzanowska-Wodnicka MAuthor
Magdalena Chrzanowska PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCell Adhesion
Cytoskeleton
Extracellular Matrix
Extracellular Matrix Proteins
GTP-Binding Proteins
Humans
Membrane Proteins
Signal Transduction
rhoB GTP-Binding Protein
