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Inputs to medullary respiratory neurons from a pontine subregion that controls breathing frequency. Respir Physiol Neurobiol 2019 Jul;265:127-140

Date

07/03/2018

Pubmed ID

29964165

Pubmed Central ID

PMC6310670

DOI

10.1016/j.resp.2018.06.011

Scopus ID

2-s2.0-85049327239 (requires institutional sign-in at Scopus site)   21 Citations

Abstract

Neurons in a subregion of the medial parabrachial (PB) complex control expiratory duration (TE) and the inspiratory on-switch. To better understanding the underlying mechanisms, this study aimed to determine the types of medullary neurons in the rhythmogenic preBötzinger/Bötzinger Complex (preBötC/BötC) and adjacent areas that receive synaptic inputs from the PB subregion and whether these inputs are excitatory or inhibitory in nature. Highly localized electrical stimuli in the PB subregion combined with multi-electrode recordings from respiratory neurons and phrenic nerve activities were used to generate stimulus-to-spike event histograms to detect correlations in decerebrate, vagotomized dogs during isocapnic hyperoxia. Short-time scale correlations were found in 237/442 or ∼54% of the ventral respiratory column (VRC) neurons. Inhibition of E-neurons was ∼2.5X greater than for I-neurons, while Pre-I and I-neurons were excited. These findings indicate that the control of TE and the inspiratory on-switch by the PB subregion are mediated by a marked inhibition of BötC E-neurons combined with an excitation of I-neurons, especially pre-I neurons.

Author List

Zuperku EJ, Stucke AG, Krolikowski JG, Tomlinson J, Hopp FA, Stuth EA

Authors

Astrid G. Stucke MD Professor in the Anesthesiology department at Medical College of Wisconsin
Eckehard A. Stuth MD Professor in the Anesthesiology department at Medical College of Wisconsin
Edward J. Zuperku PhD Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Dogs
Female
Male
Medulla Oblongata
Neurons
Parabrachial Nucleus
Phrenic Nerve
Respiratory Center
Respiratory Rate