TNFSF15 is an ethnic-specific IBD gene. Inflamm Bowel Dis 2007 Nov;13(11):1333-8
Date
08/01/2007Pubmed ID
17663424Pubmed Central ID
PMC2552994DOI
10.1002/ibd.20223Scopus ID
2-s2.0-36749055773 (requires institutional sign-in at Scopus site) 83 CitationsAbstract
BACKGROUND: Inflammatory bowel disease (IBD) is a clinically and, likely, genetically heterogeneous group of disorders. A recent report suggests that genetic variations in the TNFSF15 gene contribute to the susceptibility of IBD in both Japanese and Caucasian populations. The aim was to confirm the association between TNFSF15 high- and low-risk haplotypes and IBD in a Caucasian population.
METHODS: Five single-nucleotide polymorphisms (SNPs) that comprise the 2 common haplotypes were genotyped in 599 Caucasian patients with Crohn's disease (CD), 382 Caucasian patients with ulcerative colitis (UC), and 230 ethnically matched healthy controls, including both Jews and non-Jews.
RESULTS: The previously reported 'risk' haplotype was not associated with CD or UC (88.2% in CD cases versus 88.3% in controls, P = 0.96; 88.1% in UC cases versus 88.3% in controls, P = 0.78). We did, however, observe an increased frequency of the "protective" haplotype in non-Jewish controls for both CD and UC (38.8% CD cases versus 50% controls, P = 0.01; 37.3% UC cases versus 50% controls, P = 0.01) with no such effect observed in the Jewish samples. There was an interactive effect between ethnicity and the protective haplotype in CD (P = 0.04).
CONCLUSIONS: We observed a protective haplotype, consisting of the minor alleles for all 5 markers, to have a higher frequency in the non-Jewish controls than in CD and UC. Of further interest, the haplotype frequency was in the opposite direction in our Jewish case-control panels (both CD and UC), leading us to conclude 1) that TNFSF15 is indeed an IBD susceptibility gene, and 2) the disease susceptibility is ethnic-specific.
Author List
Picornell Y, Mei L, Taylor K, Yang H, Targan SR, Rotter JIAuthor
Ling Mei MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AllelesCase-Control Studies
Colitis, Ulcerative
Crohn Disease
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Inflammatory Bowel Diseases
Jews
Polymorphism, Single Nucleotide
Tumor Necrosis Factor Ligand Superfamily Member 15
