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Findings in Persistent Retinopathy of Prematurity. Ophthalmic Surg Lasers Imaging Retina 2018 07 01;49(7):497-503

Date

07/19/2018

Pubmed ID

30021036

Pubmed Central ID

PMC6196355

DOI

10.3928/23258160-20180628-05

Scopus ID

2-s2.0-85050358307   5 Citations

Abstract

BACKGROUND AND OBJECTIVE: To determine whether retinopathy of prematurity (ROP) that persists beyond a postmenstrual age (PMA) of 45 weeks has abnormalities that can be documented by fundus photography or fluorescein angiography (FA).

PATIENTS AND METHODS: Fundus photographs and FAs were reviewed for all premature infants who underwent FA for persistent ROP after 45 weeks PMA.

RESULTS: Of the 487 infants who were screened for ROP, 16 (3.3%) demonstrated ROP beyond 45 weeks. Seven (43.8%) infants received prior treatment with intravitreal bevacizumab (IVB) for Type 1 ROP. FAs were obtained in eight cases; four subjects were previously treated with IVB. Leakage at the vascular-avascular border was demonstrated in seven subjects (87.5%). Shunt vessels, posterior retinal nonperfusion, and absence of the foveal avascular zone was limited to the IVB group.

CONCLUSIONS: There are persistent vascular abnormalities among infants with ROP beyond 45 weeks. Findings that may be missed by RetCam fundus photographs were highlighted with FA. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:497-503.].

Author List

Warren CC, Young JB, Goldberg MR, Connor TB, Kassem IS, Costakos DM

Authors

Thomas B. Connor MD Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
Deborah M. Costakos MD Chair, Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
Iris S. Kassem MD, PhD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin
Clinton Warren MD Assistant Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Angiogenesis Inhibitors
Bevacizumab
Fluorescein Angiography
Gestational Age
Humans
Infant, Extremely Low Birth Weight
Infant, Premature
Intravitreal Injections
Photography
Retinal Vessels
Retinopathy of Prematurity
Retrospective Studies
Vascular Endothelial Growth Factor A