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Transient species in the stepwise interconversion of NADH and NAD+. Acc Chem Res 2004 Jun;37(6):379-86

Date

06/16/2004

Pubmed ID

15196047

DOI

10.1021/ar030171j

Scopus ID

2-s2.0-2942637485 (requires institutional sign-in at Scopus site)   137 Citations

Abstract

Two mechanisms of the interconversion of NADH and NAD+ in the coenzyme itself and in its analogues are discussed: a one-step hydride transfer and a stepwise electron-proton-electron transfer. Direct characterization of the transient species in the stepwise process and inversion of the stability order of the keto and enol tautomers is presented. The nonenzymatic and enzyme-mediated reactions of selected pyridinium salts that affect the NADH <==>NAD+ equilibrium are discussed in terms of their potential cytotoxicity.

Author List

Gebicki J, Marcinek A, Zielonka J

Author

Jacek M. Zielonka PhD Assistant Professor in the Biophysics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cations
Free Radicals
Humans
NAD