Transient species in the stepwise interconversion of NADH and NAD+. Acc Chem Res 2004 Jun;37(6):379-86
Date
06/16/2004Pubmed ID
15196047DOI
10.1021/ar030171jScopus ID
2-s2.0-2942637485 (requires institutional sign-in at Scopus site) 137 CitationsAbstract
Two mechanisms of the interconversion of NADH and NAD+ in the coenzyme itself and in its analogues are discussed: a one-step hydride transfer and a stepwise electron-proton-electron transfer. Direct characterization of the transient species in the stepwise process and inversion of the stability order of the keto and enol tautomers is presented. The nonenzymatic and enzyme-mediated reactions of selected pyridinium salts that affect the NADH <==>NAD+ equilibrium are discussed in terms of their potential cytotoxicity.
Author List
Gebicki J, Marcinek A, Zielonka JAuthor
Jacek M. Zielonka PhD Assistant Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsCations
Free Radicals
Humans
NAD