Association Between Serum 25-Hydroxyvitamin D Level and Human Papillomavirus Cervicovaginal Infection in Women in the United States. J Infect Dis 2016 Jun 15;213(12):1886-92
Date
02/26/2016Pubmed ID
26908722DOI
10.1093/infdis/jiw065Scopus ID
2-s2.0-84974622974 (requires institutional sign-in at Scopus site) 26 CitationsAbstract
BACKGROUND: A sufficient level of vitamin D enhances protection against several infectious diseases; however, its association with cervicovaginal human papillomavirus (HPV) infection has not been studied.
METHODS: Data for this cross-sectional study were from National Health and Nutrition Examination Survey 2003-2006. A total of 2353 sexually active women for whom cervicovaginal HPV infection status and serum 25-hydroxyvitamin D (25[OH]D) level were known were studied. Associations between serum 25(OH)D levels (continuous and categorical forms) and cervicovaginal HPV infection (due to high-risk HPV or vaccine-type HPV) were estimated using weighted logistic regression.
RESULTS: After adjustment for age, race/ethnicity, and marital status, the odds of high-risk HPV infection were increased per each 10 ng/mL decrease in serum 25(OH)D level (adjusted odds ratio [aOR], 1.14; 95% confidence interval [CI], 1.02-1.27). Similarly, the odds of vaccine-type HPV infection were increased in women with vitamin D levels that were severely deficient (serum 25[OH]D level, <12 ng/mL; aOR, 2.90; 95% CI, 1.32-6.38), deficient (12-19 ng/mL; aOR, 2.19; 95% CI, 1.08-4.45), and insufficient (20-29 ng/mL; aOR, 2.19; 95% CI, 1.22-3.93), compared with those with vitamin D levels that were sufficient (≥30 ng/mL).
CONCLUSIONS: Cervicovaginal HPV prevalence is associated with less-than-optimal levels of serum vitamin D.
Author List
Shim J, Pérez A, Symanski E, Nyitray AGAuthor
Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Cervix Uteri
Cross-Sectional Studies
Female
Humans
Logistic Models
Middle Aged
Nutrition Surveys
Odds Ratio
Papillomaviridae
Papillomavirus Infections
Prevalence
United States
Vitamin D
Vitamin D Deficiency
Young Adult