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Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso. PLoS One 2016;11(1):e0145308

Date

01/06/2016

Pubmed ID

26731649

Pubmed Central ID

PMC4701492

DOI

10.1371/journal.pone.0145308

Scopus ID

2-s2.0-84953889084 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

Members of the Anopheles gambiae species complex are primary vectors of human malaria in Africa. Population heterogeneities for ecological and behavioral attributes expand and stabilize malaria transmission over space and time, and populations may change in response to vector control, urbanization and other factors. There is a need for approaches to comprehensively describe the structure and characteristics of a sympatric local mosquito population, because incomplete knowledge of vector population composition may hinder control efforts. To this end, we used a genome-wide custom SNP typing array to analyze a population collection from a single geographic region in West Africa. The combination of sample depth (n = 456) and marker density (n = 1536) unambiguously resolved population subgroups, which were also compared for their relative susceptibility to natural genotypes of Plasmodium falciparum malaria. The population subgroups display fluctuating patterns of differentiation or sharing across the genome. Analysis of linkage disequilibrium identified 19 new candidate genes for association with underlying population divergence between sister taxa, A. coluzzii (M-form) and A. gambiae (S-form).

Author List

Markianos K, Bischoff E, Mitri C, Guelbeogo WM, Gneme A, Eiglmeier K, Holm I, Sagnon N, Vernick KD, Riehle MM

Author

Michelle M. Riehle PhD Associate Professor in the Microbiology and Immunology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Anopheles
Burkina Faso
Genetic Structures
Genetics, Population
Genome, Insect
Genotype
Geography
Humans
Insect Vectors
Linkage Disequilibrium
Malaria, Falciparum
Phylogeny
Polymorphism, Single Nucleotide
Population Dynamics
Species Specificity