Cell-cycle regulated expression of Rap1 in regenerating liver. Biochem Biophys Res Commun 1997 Jan 23;230(3):578-81
Date
01/23/1997Pubmed ID
9015365DOI
10.1006/bbrc.1996.6003Scopus ID
2-s2.0-0031584079 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Rap1 proteins are capable of competing with Ras p21 for binding to effectors, and of antagonizing some Ras-induced effects, but their participation in normal growth regulation has not been established. The level of Rap1 protein and the expression of the rap1A gene were examined by immunoblotting and Northern analysis during the regenerative growth response in rat liver following partial hepatectomy. Protein and mRNA were significantly down-regulated prior to and during the onset of DNA synthesis. The timing of this effect is consistent with a model in which expression of Rap1 is turned off or down to allow the initiation of proliferation.
Author List
Cruise JL, Rafferty MP, Riehle MMAuthor
Michelle M. Riehle PhD Assistant Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiological Transport
Cell Cycle
Cell Membrane
Female
GTP-Binding Proteins
Liver
Liver Regeneration
Proto-Oncogene Proteins
RNA, Messenger
Rats
Rats, Inbred F344
rap GTP-Binding Proteins
