Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation. Pain 2018 Sep;159 Suppl 1(Suppl 1):S91-S97
Date
08/17/2018Pubmed ID
30113953Pubmed Central ID
PMC6097240DOI
10.1097/j.pain.0000000000001235Scopus ID
2-s2.0-85063171968 (requires institutional sign-in at Scopus site) 222 CitationsAbstract
An acute bout of physical activity and exercise can increase pain in individuals with chronic pain, but regular exercise is an effective treatment. This review will discuss these two dichotomous findings by summarizing studies in human and animal subjects. We will provide the data that supports the role of physical activity in modulating central nervous system excitability and inhibition, immune system function, and psychological constructs associated with pain. We show evidence that the sedentary condition is associated with greater excitability and less inhibition in both the central nervous system (brainstem inhibitory/facilitatory sites) and the immune system. We further show that exercise and regular physical activity decreases excitability and improves inhibition in both the central nervous system (brainstem inhibitory/facilitatory sites) and the immune system. We will then discuss the clinical implications of these findings, make recommendations for clinical application of exercise, and suggest future research directions.
Author List
Sluka KA, Frey-Law L, Hoeger Bement MAuthor
Marie Hoeger Bement MPT,PhD Associate Professor in the Physical Therapy department at Marquette UniversityMESH terms used to index this publication - Major topics in bold
AnalgesiaAnimals
Clinical Trials as Topic
Exercise
Humans
Immune System
Pain
