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Mitochondrial regulation of diabetic vascular disease: an emerging opportunity. Transl Res 2018 12;202:83-98

Date

08/26/2018

Pubmed ID

30144425

Pubmed Central ID

PMC6218302

DOI

10.1016/j.trsl.2018.07.015

Scopus ID

2-s2.0-85052836555   8 Citations

Abstract

Diabetes-related vascular complication rates remain unacceptably high despite guideline-based medical therapies that are significantly more effective in individuals without diabetes. This critical gap represents an opportunity for researchers and clinicians to collaborate on targeting mechanisms and pathways that specifically contribute to vascular pathology in patients with diabetes mellitus. Dysfunctional mitochondria producing excessive mitochondrial reactive oxygen species (mtROS) play a proximal cell-signaling role in the development of vascular endothelial dysfunction in the setting of diabetes. Targeting the mechanisms of production of mtROS or mtROS themselves represents an attractive method to reduce the prevalence and severity of diabetic vascular disease. This review focuses on the role of mitochondria in the development of diabetic vascular disease and current developments in methods to improve mitochondrial health to improve vascular outcomes in patients with DM.

Author List

Widlansky ME, Hill RB

Authors

Ronald Blake Hill PhD Professor in the Biochemistry department at Medical College of Wisconsin
Michael E. Widlansky MD Associate Director, Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Diabetic Angiopathies
Endothelium, Vascular
Humans
Mitochondria
Mitochondrial Proteins
Reactive Oxygen Species
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