Physiological Consequences of Coronary Arteriolar Dysfunction and Its Influence on Cardiovascular Disease. Physiology (Bethesda) 2018 Sep 01;33(5):338-347
Date
08/16/2018Pubmed ID
30109826Pubmed Central ID
PMC6230549DOI
10.1152/physiol.00019.2018Scopus ID
2-s2.0-85056490489 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
To date, the major focus of diagnostic modalities and interventions to treat coronary artery disease has been the large epicardial vessels. Despite substantial data showing that microcirculatory dysfunction is a strong predictor of future adverse cardiovascular events, very little research has gone into developing techniques for in vivo diagnosis and therapeutic interventions to improve microcirculatory function. In this review, we will discuss the pathophysiology of coronary arteriolar dysfunction, define its prognostic implications, evaluate the diagnostic modalities available, and provide speculation on current and potential therapeutic opportunities.
Author List
Allaqaband H, Gutterman DD, Kadlec AOMESH terms used to index this publication - Major topics in bold
AnimalsArterioles
Cardiovascular Diseases
Coronary Artery Disease
Humans
Microcirculation
Microvessels
Prognosis