Ascorbate attenuates red light mediated vasodilation: Potential role of S-nitrosothiols. Redox Biol 2019 Jan;20:13-18
Date
09/28/2018Pubmed ID
30261342Pubmed Central ID
PMC6156744DOI
10.1016/j.redox.2018.09.008Scopus ID
2-s2.0-85053754114 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
There is significant therapeutic advantage of nitric oxide synthase (NOS) independent nitric oxide (NO) production in maladies where endothelium, and thereby NOS, is dysfunctional. Electromagnetic radiation in the red and near infrared region has been shown to stimulate NOS-independent but NO-dependent vasodilation, and thereby has significant therapeutic potential. We have recently shown that red light induces acute vasodilatation in the pre-constricted murine facial artery via the release of an endothelium derived substance. In this study we have investigated the mechanism of vasodilatation and conclude that 670 nm light stimulates vasodilator release from an endothelial store, and that this vasodilator has the characteristics of an S-nitrosothiol (RSNO). This study shows that 670 nm irradiation can be used as a targeted and non-invasive means to release biologically relevant amounts of vasodilator from endothelial stores. This raises the possibility that these stores can be pharmacologically built-up in pathological situations to improve the efficacy of red light treatment. This strategy may overcome eNOS dysfunction in peripheral vascular pathologies for the improvement of vascular health.
Author List
Keszler A, Lindemer B, Hogg N, Lohr NLAuthors
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinAgnes Keszler PhD Research Scientist I in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AcetylcholineAnimals
Arteries
Ascorbic Acid
Light
Mice
Models, Biological
Nitric Oxide
Nitric Oxide Synthase Type II
S-Nitrosothiols
Vasodilation
Vasodilator Agents