Strategies for carbohydrate recognition by the mannose 6-phosphate receptors. Glycobiology 2008 Sep;18(9):664-78
Date
07/16/2008Pubmed ID
18621992Pubmed Central ID
PMC2733771DOI
10.1093/glycob/cwn061Scopus ID
2-s2.0-58149107948 (requires institutional sign-in at Scopus site) 91 CitationsAbstract
The two members of the P-type lectin family, the 46 kDa cation-dependent mannose 6-phosphate receptor (CD-MPR) and the 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR), are ubiquitously expressed throughout the animal kingdom and are distinguished from all other lectins by their ability to recognize phosphorylated mannose residues. The best-characterized function of the MPRs is their ability to direct the delivery of approximately 60 different newly synthesized soluble lysosomal enzymes bearing mannose 6-phosphate (Man-6-P) on their N-linked oligosaccharides to the lysosome. In addition to its intracellular role in lysosome biogenesis, the CI-MPR, but not the CD-MPR, participates in a number of other biological processes by interacting with various molecules at the cell surface. The list of extracellular ligands recognized by this multifunctional receptor has grown to include a diverse spectrum of Man-6-P-containing proteins as well as several non-Man-6-P-containing ligands. Recent structural studies have given us a clearer view of how these two receptors use related, but yet distinct, approaches in the recognition of phosphomannosyl residues.
Author List
Dahms NM, Olson LJ, Kim JJAuthors
Nancy M. Dahms PhD Professor in the Biochemistry department at Medical College of WisconsinJung Ja P. Kim PhD Professor in the Biochemistry department at Medical College of Wisconsin
Linda J. Olson PhD Assistant Professor in the Biophysics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Amino Acid SequenceAnimals
Binding Sites
Carbohydrate Metabolism
Crystallography, X-Ray
Glycoproteins
Humans
Mannosephosphates
Models, Biological
Models, Molecular
Molecular Sequence Data
Oligosaccharides
Protein Binding
Receptor, IGF Type 2
Sequence Homology, Amino Acid
