Faculty Collaboration Database

Evaluation, Staging, and Surgical Management for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group. Ann Surg Oncol 2018 Nov;25(12):3460-3468

Date

09/20/2018

Pubmed ID

30229419

DOI

10.1245/s10434-018-6749-2

Scopus ID

2-s2.0-85053523148 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

This is the first of a two-part review on adrenocortical carcinoma (ACC), a rare and aggressive malignancy that often presents at an advanced stage. Most patients present with symptoms related to cortisol and/or androgen excess. Appropriate biochemical evaluation and imaging is important in assessing the extent of disease, operative planning, and oncologic surveillance for patients with ACC. For patients with locoregional disease, potential cure requires margin-negative resection, and accumulating evidence suggests that regional lymphadenectomy should be performed. Although laparoscopic adrenalectomy is reported by some to be adequate for localized ACC, open resection in the hands of an experienced adrenal surgeon is the gold standard for operative management of this disease. Cure is rare following disease relapse, however select patients with severe symptoms related to hormone excess or pain may benefit from resection of local or distant recurrence. For best oncologic outcomes, it is recommended that all patients with ACC be treated at centers with multidisciplinary expertise in management of this rare and aggressive malignancy.

Author List

Dickson PV, Kim L, Yen TWF, Yang A, Grubbs EG, Patel D, Solórzano CC

Author

Tina W F Yen MD, MS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenal Cortex Neoplasms
Adrenalectomy
Adrenocortical Carcinoma
Diagnostic Imaging
Disease Management
Humans
Laparoscopy
Lymph Node Excision
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis