Zika Virus-Associated Cerebellitis with Complete Clinical Recovery. Am J Trop Med Hyg 2018 Nov;99(5):1318-1320
Date
09/27/2018Pubmed ID
30255830Pubmed Central ID
PMC6221247DOI
10.4269/ajtmh.18-0261Scopus ID
2-s2.0-85056268902 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Zika virus (ZIKV) was first detected in the Americas in Brazil in 2015, with a rapid spread to surrounding countries. In Panama, the outbreak began in November 2015 in an indigenous community located on the Caribbean side of the country. Zika virus is typically associated with a diffuse rash, fever, and conjunctivitis. It can rarely cause neurologic manifestations, most commonly microcephaly and Guillain-Barré syndrome. Encephalitis and acute encephalomyelitis are known complications, but ZIKV-associated cerebellitis has yet to be reported in the literature. Herein, we report a case of cerebellitis in a patient infected with ZIKV. This patient developed severe frontal headache and vertigo on the third day of illness, and dysarthria and ataxia on the fifth day. After 1 week of hospitalization, the patient completely recovered. The laboratory serological diagnosis was complicated because of the detection of antibodies against dengue, suggesting a secondary flavivirus infection.
Author List
Pachar MR, Araúz D, Gundacker ND, Suárez M, Suárez JA, Moreno B, López-Vergès S, Araúz ABAuthor
Nathan D. Gundacker MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAntibodies, Viral
Ataxia
Brazil
Cerebellar Diseases
Coinfection
Dengue
Female
Flavivirus Infections
Headache
Hospitalization
Humans
Polymerase Chain Reaction
RNA, Viral
Tomography, X-Ray Computed
Treatment Outcome
Vertigo
Zika Virus
Zika Virus Infection