Faculty Collaboration Database

Methotrexate-induced Leukoencephalopathy without Typical Restricted Diffusion on Diffusion-weighted Imaging and the Utility of Magnetic Resonance Spectroscopy to Support the Diagnosis. Asian J Neurosurg 2018;13(3):848-850

Date

10/05/2018

Pubmed ID

30283563

Pubmed Central ID

PMC6159078

DOI

10.4103/ajns.AJNS_324_16

Abstract

Methotrexate (MTX) is a common antimetabolite agent that is widely used today in treating leukemia, lymphoma, and osteosarcoma. Its use has been associated with leukoencephalopathy causing seizures, paralysis, and even coma. To achieve the best possible outcome, it is important to be able to make a prompt diagnosis. Studies reported restricted diffusion on diffusion-weighted imaging (DWI) which is a reliable early sign of acute MTX-induced leukoencephalopathy. However, we report here the first case of MTX-induced leukoencephalopathy without typical restricted diffusion on DWI and the utility magnetic resonance spectroscopy to support this diagnosis in the difficult case such as the one being presented here.

Author List

Doan N, Patel M, Nguyen HS, Doan H, Shabani S, Gelsomino M, Mountoure A, Janich K, Chitambar CR

Author

Saman Shabani MD Assistant Professor in the Neurosurgery department at Medical College of Wisconsin