Indolent peripheral T-cell lymphoma involving the gastrointestinal tract. Hum Pathol 2014 Feb;45(2):421-6
Date
01/21/2014Pubmed ID
24439229DOI
10.1016/j.humpath.2013.08.003Scopus ID
2-s2.0-84892752498 (requires institutional sign-in at Scopus site) 34 CitationsAbstract
We describe an unusual case of indolent peripheral T-cell lymphoma with multifocal involvement of the gastrointestinal tract. The patient, a 42-year-old Asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. Histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and clear cytoplasm and rare large lymphocytes. The tumor cells were positive for CD3, CD8, granzyme B, and TIA-1 (subset) and negative for CD5, CD56, and Epstein-Barr virus-encoded RNA. Molecular studies for T-cell receptor γ and/or β chain gene rearrangement demonstrated the same clone at different sites and times during the course of the disease. Rare cases of indolent peripheral T-cell lymphoma of the gastrointestinal tract have been previously described and need to be further characterized to avoid the use of aggressive chemotherapy.
Author List
Leventaki V, Manning JT Jr, Luthra R, Mehta P, Oki Y, Romaguera JE, Medeiros LJ, Vega FMESH terms used to index this publication - Major topics in bold
AdultGastrointestinal Neoplasms
Gastrointestinal Tract
Humans
Lymphoma, T-Cell, Peripheral
Male