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Incidence and survival of T-cell acute lymphoblastic leukemia in the United States. Leuk Lymphoma 2019 May;60(5):1171-1178

Date

11/09/2018

Pubmed ID

30407885

DOI

10.1080/10428194.2018.1522442

Scopus ID

2-s2.0-85057299329   14 Citations

Abstract

T-cell acute lymphoblastic leukemia (T-ALL) is a curable malignancy in the pediatric population. However, population-level data on its incidence and outcomes among adults is sparse. Using SEER database, we identified 1141 patients aged ≥20 years with pathologically confirmed T-ALL diagnosed between the years 2001 and 2014 and actively followed. Incidence of T-ALL was 0.13 cases/100,000 population with significant variations by age, gender, race, and period. The 5-year overall survival (OS) declined significantly with increasing age (age <40, 51.9%; age 40-59, 37.3%; age 60-79, 19.2%; age ≥80, 0%; p < .001) and varied by race (whites - 45.7%, blacks - 25.1%, others - 40.3%; p < .001). Over time, OS has improved significantly in patients <60 years (2001-2007, 42.8% vs 2008-2014, 53.1%; p = .005), but not in patients older than 60 years (2001-2007, 18% vs 2008-2014, 22.8%; p = .71), highlighting the need for effective and safe treatments in this population.

Author List

Guru Murthy GS, Pondaiah SK, Abedin S, Atallah E

Authors

Sameem Abedin MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Ehab L. Atallah MD Professor in the Medicine department at Medical College of Wisconsin
Guru Subramanian Guru Murthy MD Assistant Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Age Factors
Aged
Aged, 80 and over
Disease Management
Female
Humans
Incidence
Male
Middle Aged
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Public Health Surveillance
SEER Program
Survival Rate
United States
Young Adult