Faculty Collaboration Database

Selection of Patients With Localized Extremity Soft Tissue Sarcoma for Treatment With Perioperative Chemotherapy. Curr Treat Options Oncol 2018 Oct 25;19(12):65

Date

10/27/2018

Pubmed ID

30361919

DOI

10.1007/s11864-018-0586-1

Scopus ID

2-s2.0-85055453382 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

Soft tissue sarcoma (STS) is a heterogeneous disease, in terms of histologic subtype, body site of presentation, and behavior. Localized soft tissue sarcoma may be cured with complete tumor excision, but overall, outcomes are sub-optimal. Metastatic disease is associated with shortened survival. Systemic therapy has been studied for several decades as adjunctive therapy, but the use of adjuvant and neo-adjuvant chemotherapy remains controversial. The heterogeneity of patients included in clinical trials, and of sarcoma in general, has made it difficult to draw conclusions about which patients with localized STS should be treated with chemotherapy. Over time, published outcomes for STS of the extremities have improved, and one of the factors that contributes to this improvement may be selection of patients most likely to benefit from the prescribed treatment. Recent studies of neo-adjuvant and adjuvant chemotherapy have recruited patients with the highest recurrence risk-those with large, high-grade, deep tumors. It is reasonable, in practice, to apply similar criteria in deciding whether to recommend treatment. Looking ahead, it will be important to refine our ability to identify patients at highest risk of recurrence, and to develop tools to predict which patients and tumors will respond to chemotherapy.

Author List

Charlson J

Author

John A. Charlson MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Antineoplastic Combined Chemotherapy Protocols
Chemotherapy, Adjuvant
Combined Modality Therapy
Doxorubicin
Epirubicin
Humans
Ifosfamide
Neoplasm Metastasis
Neoplasm Recurrence, Local
Sarcoma
Soft Tissue Neoplasms