Dye-mediated photolysis of human neuroblastoma cells: implications for autologous bone marrow transplantation. Blood 1986 Jul;68(1):32-6
Date
07/01/1986Pubmed ID
3521764DOI
10.1182/blood.v68.1.32.bloodjournal68132Scopus ID
2-s2.0-0022511895 (requires institutional sign-in at Scopus site) 69 CitationsAbstract
Cells from three different human neuroblastoma cell lines and normal human bone marrow cells were exposed to the lipophilic fluorescent dye, merocyanine 540 (MC 540), and white light. In vitro clonogenic tumor cells were inactivated up to 25,000 times more rapidly than multipotent hematopoietic progenitor cells (CFU-GEMM). It is conceivable that this pronounced difference in sensitivity to MC 540-mediated photolysis can be exploited for the selective killing of residual neuroblastoma cells in autologous remission marrow grafts.
Author List
Sieber F, Rao S, Rowley SD, Sieber-Blum MAuthor
Fritz Sieber PhD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Bone MarrowBone Marrow Transplantation
Cell Line
Cell Survival
Hematopoietic Stem Cells
Humans
Neoplastic Stem Cells
Neuroblastoma
Photolysis
Pyrimidinones
Transplantation, Autologous