Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. Annu Rev Microbiol 2008;62:271-88
Date
09/13/2008Pubmed ID
18785839DOI
10.1146/annurev.micro.62.081307.162848Scopus ID
2-s2.0-53849133471 (requires institutional sign-in at Scopus site) 137 CitationsAbstract
Bacterial pathogens utilize toxins to modify or kill host cells. The bacterial ADP-ribosyltransferases are a family of protein toxins that covalently transfer the ADP-ribose portion of NAD to host proteins. Each bacterial ADP-ribosyltransferase toxin modifies a specific host protein(s) that yields a unique pathology. These toxins possess the capacity to enter a host cell or to use a bacterial Type III apparatus for delivery into the host cell. Advances in our understanding of bacterial toxin action parallel the development of biophysical and structural biology as well as our understanding of the mammalian cell. Bacterial toxins have been utilized as vaccines, as tools to dissect host cell physiology, and more recently for the development of novel therapies to treat human disease.
Author List
Deng Q, Barbieri JTAuthor
Joseph T. Barbieri PhD Professor in the Microbiology and Immunology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
ADP Ribose TransferasesAdenosine Diphosphate Ribose
Animals
Bacterial Toxins
Cytotoxins
Diphtheria Toxin
Exotoxins
GTPase-Activating Proteins
Humans
Leukocidins
Models, Biological
Models, Molecular
Peptide Elongation Factor 2
Virulence Factors