High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression. Microcirculation 2019 Apr;26(3):e12518
Date
11/28/2018Pubmed ID
30481399Pubmed Central ID
PMC6465152DOI
10.1111/micc.12518Scopus ID
2-s2.0-85060177536 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
OBJECTIVES: This study sought to determine whether salt-induced ANG II suppression contributes to impaired CBF autoregulation.
METHODS: Cerebral autoregulation was evaluated with LDF during graded reductions of blood pressure. Autoregulatory responses in rats fed HS (4% NaCl) diet vs LS (0.4% NaCl) diet were analyzed using linear regression analysis, model-free analysis, and a mechanistic theoretical model of blood flow through cerebral arterioles.
RESULTS: Autoregulation was intact in LS-fed animals as MAP was reduced via graded hemorrhage to approximately 50 mm Hg. Short-term (3 days) and chronic (4 weeks) HS diet impaired CBF autoregulation, as evidenced by progressive reductions of laser Doppler flux with arterial pressure reduction. Chronic low dose ANG II infusion (5 mg/kg/min, i.v.) restored CBF autoregulation between the pre-hemorrhage MAP and 50 mm Hg in rats fed short-term HS diet. Mechanistic-based model analysis showed a reduced myogenic response and reduced baseline VSM tone with short-term HS diet, which was restored by ANG II infusion.
CONCLUSIONS: Short-term and chronic HS diet lead to impaired autoregulation in the cerebral circulation, with salt-induced ANG II suppression as a major factor in the initiation of impaired CBF regulation.
Author List
Allen LA, Schmidt JR, Thompson CT, Carlson BE, Beard DA, Lombard JHMESH terms used to index this publication - Major topics in bold
Angiotensin IIAnimals
Blood Flow Velocity
Blood Pressure
Cerebral Arteries
Cerebrovascular Circulation
Rats
Rats, Sprague-Dawley
Sodium Chloride, Dietary
