Wound healing after filtering surgery in owl monkeys. Arch Ophthalmol 1986 Dec;104(12):1835-9
Date
12/01/1986Pubmed ID
3789983DOI
10.1001/archopht.1986.01050240109050Scopus ID
2-s2.0-0022974460 (requires institutional sign-in at Scopus site) 99 CitationsAbstract
We performed posterior lip sclerectomies in 29 owl monkey eyes to determine the natural history of wound healing after filtering surgery without adjunctive antimetabolite therapy. We noted three phases of wound healing during clinical and histologic examination: early healing (days 2 to 6), intermediate healing (days 7 to 9), and late healing (days 10 to 14). In the early healing phase, all limbal fistulas except one remained open gonioscopically, but by day 6, fibroblasts had proliferated along the walls of the opening. Proliferation and migration of fibroblasts continued during the intermediate healing phase to completely occlude four and to partially occlude two of the ten fistulas in the eyes studied during this time. In the late healing phase, the limbal fistula was completely closed by granulation tissue in four of five eyes and was slitlike open in one eye. In this model of filtering surgery, wound healing at the sclerectomy site with obliteration of the limbal opening by proliferating fibroblasts occurred within the first 14 postoperative days. We believe that the short-term effects of newer treatments designed to alter wound healing after filtering surgery may be assessed in this model, which is characterized by predictable and prompt wound healing.
Author List
Desjardins DC, Parrish RK 2nd, Folberg R, Nevarez J, Heuer DK, Gressel MGAuthor
Dale Heuer MD Emeritus Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAotus trivirgatus
Glaucoma
Mice
Postoperative Period
Sclera
Time Factors
Wound Healing
