Strain Variation and Disease Severity in Congenital Cytomegalovirus Infection: In Search of a Viral Marker. Infect Dis Clin North Am 2015 Sep;29(3):401-14
Date
07/15/2015Pubmed ID
26154664Pubmed Central ID
PMC4552582DOI
10.1016/j.idc.2015.05.009Scopus ID
2-s2.0-84952876265 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
The wide spectrum of congenital cytomegalovirus (CMV) disease and known differences in the biology and in vitro growth of CMV strains continue to drive studies in search for specific viral genetic determinants that may predict severity of congenital CMV disease. Several CMV genes have been studied in detail in congenitally infected children, but the complexity of the viral genome and differences in the definition of symptomatic disease versus asymptomatic CMV infection continue to raise questions related to what constitutes a pathogenic CMV strain.
Author List
Arav-Boger RAuthor
Ravit Boger MD Chief, Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BiomarkersChild
Cytomegalovirus
Cytomegalovirus Infections
Genes, Viral
Genetic Variation
Genotype
High-Throughput Nucleotide Sequencing
Humans
Immune Evasion
Infant
Membrane Glycoproteins
Viral Proteins