Faculty Collaboration Database

Prevention and control of neoplasms associated with HPV in high-risk groups in Mexico City: The Condesa Study. Salud Publica Mex 2018;60(6):703-712

Date

01/31/2019

Pubmed ID

30699275

DOI

10.21149/10034

Scopus ID

2-s2.0-85059201245 (requires institutional sign-in at Scopus site)   9 Citations

Abstract

OBJECTIVE: To evaluate the effectiveness of a combined strategy of human papillomavirus virus (HPV) vaccination and high-risk HPV screening to reduce the occurrence of anogenital and oropharyngeal neoplasms among men who have sex with men, people with HIV, homeless people, transgender women, female sex workers and rape victims.

MATERIALS AND METHODS: This mixed methods study evaluates the effectiveness of a combined vaccination-screening strategy to reduce HPV prevalence/incidence and occurrence of cervical intraepithelial neoplasms grade 2+ and/or anal intraepithelial neoplasms grade 2+, using Kaplan-Meier. The time-to-event method will evaluate time from positive results for specific anogenital HPV to incidence of anogenital lesions containing that HPV type.

RESULTS: People vaccinated against HPV and screened for HPV as a primary test will have lower prevalence and incidence of HPV infection and consequently lower frequency of HPV-related anogenital and oropharyngeal lesions.

CONCLUSIONS: Thisstudy will generate scientific evidence on effectiveness of a combined vaccination-screening strategy to reduce the burden of HPV-associated neoplasms.

Author List

Lazcano-Ponce E, Salmerón J, González A, Allen-Leigh B, León-Maldonado L, Magis C, Aranda-Flores C, Conde-González C, Portillo-Romero AJ, Yunes-Díaz E, Rivera-Rivera L, Vargas G, Nyitray AG, Giuliano AR

Author

Alan Nyitray PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Anus Neoplasms
Carcinoma in Situ
Comorbidity
Crime Victims
Early Detection of Cancer
Female
HIV Infections
Humans
Immunization Programs
Male
Mexico
Mouth Neoplasms
Papillomavirus Infections
Papillomavirus Vaccines
Program Evaluation
Risk
Sexual Behavior
Sexual and Gender Minorities
Social Marginalization
Urban Population
Uterine Cervical Dysplasia
Uterine Cervical Neoplasms
Vaccination
Vulnerable Populations
Young Adult