Transgenic animals in the study of blood pressure regulation and hypertension. Am J Physiol 1995 Nov;269(5 Pt 1):E793-803
Date
11/01/1995Pubmed ID
7491928DOI
10.1152/ajpendo.1995.269.5.E793Scopus ID
2-s2.0-0028881235 (requires institutional sign-in at Scopus site) 18 CitationsAbstract
It is generally accepted that the etiology of essential hypertension is due to a complex interplay of genetic and environmental factors. A great deal of research effort over the past ten years has been focused on the identification of genes the variants of which predispose individuals to high blood pressure. Consequently, transgenic and knockout animals have become important research tools, providing experimental systems in which defined genetic manipulations can be introduced on uniform genetic backgrounds while minimizing environmental variation. These animal models have provided the means by which candidate genes thought to be involved in blood pressure regulation have been studied. Furthermore, these models can be used to test the significance of genes and gene variants identified via genome-wide searches as potential causes of hypertension. The purpose of this review is to provide a brief discussion of transgenic and knockout methodology and its application to study the genetic basis of hypertension.
Author List
Thompson MW, Merrill DC, Yang G, Robillard JE, Sigmund CDAuthor
Curt Sigmund PhD Chair, Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AngiotensinogenAnimals
Animals, Genetically Modified
Blood Pressure
Gene Expression
Gene Expression Regulation
Hypertension
Mice
Mice, Transgenic
