Human renin 5'-flanking DNA to nucleotide-2750. DNA Seq 1995;5(5):319-21
Date
01/01/1995Pubmed ID
7579588DOI
10.3109/10425179509030988Scopus ID
2-s2.0-0028873963 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
Renin is one of the most important factors in blood pressure and electrolyte regulation in mammals and the renin locus has been implicated in hypertension. To assist studies of promoter control we therefore determined the 5'-flanking sequence of the human gene (REN) to residue -2750 relative to the transcription start site (+1). Sites of homology to consensus sequences for binding of trans-acting factors involved in transcriptional control of other genes were identified, and functionality for two of these (a CRE and Pit-1 site) have so far been demonstrated.
Author List
Smith DL, Jeyapalan S, Lang JA, Guo XH, Sigmund CD, Morris BJAuthor
Curt Sigmund PhD Chair, Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Base SequenceConsensus Sequence
Genomic Library
Humans
Molecular Sequence Data
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid
Renin
Sequence Analysis, DNA