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Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue. Biochem Biophys Res Commun 1990 Nov 30;173(1):218-23

Date

11/30/1990

Pubmed ID

1979487

DOI

10.1016/s0006-291x(05)81044-7

Scopus ID

2-s2.0-0025686098   9 Citations

Abstract

We have previously identified peripheral subcutaneous tissue as a bonafide site of primary renin expression in the mouse fetus by virtue of oncogene mediated tumorigenesis in transgenic mice. In this report we demonstrate that the murine renin genes are differentially expressed in this tissue. Through selective breeding and differential primer extension we demonstrate that Ren-1d and Ren-1c transcripts were several fold more abundant than Ren-2. Renin transcripts were also identified in fetal subcutaneous tissues of Spontaneously Hypertensive (SHR) and Wistar Kyoto (WKY) rats. We conclude from these studies that expression of renin during fetal development may be widespread in rodents with its temporal and spatial localization consistent with a role in fetal development.

Author List

Sigmund CD, Gross KW

Author

Curt Sigmund PhD Chair, Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Crosses, Genetic
Female
Fetus
Gene Expression Regulation, Enzymologic
Genotype
Mice
Mice, Inbred DBA
Mice, Inbred Strains
Mice, Transgenic
Neoplasms, Experimental
Nucleic Acid Hybridization
Polymorphism, Restriction Fragment Length
Pregnancy
Promoter Regions, Genetic
RNA, Messenger
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Renin
Restriction Mapping
Transcription, Genetic