Risk of miscarriage and a common variant of the estrogen receptor gene. Am J Epidemiol 1993 Jun 15;137(12):1361-4
Date
06/15/1993Pubmed ID
8333417DOI
10.1093/oxfordjournals.aje.a116645Scopus ID
2-s2.0-0027320809 (requires institutional sign-in at Scopus site) 22 CitationsAbstract
An inherited variant of the estrogen receptor gene was previously suggested to be a major determinant of a woman's risk of miscarriage. The authors tested this hypothesis in a case-control study of 29 women who had had two or more miscarriages and 29 women with no miscarriages. All of the women had given birth in North Carolina between 1987 and 1990. Estrogen receptor genotype was determined by direct sequencing of DNA. The gene variant that supposedly produced the risk was found to contain only a silent substitution at codon 87. Furthermore, instead of an odds ratio of 25 (predicted by the previous study), the odds ratio found was 1.8 (95% confidence interval 0.3-11). For a hypothesis which now lacks biologic plausibility, this weak association provides little reason for further investigation.
Author List
Taylor JA, Wilcox AJ, Bowes WA, Li Y, Liu ET, You MMESH terms used to index this publication - Major topics in bold
Abortion, SpontaneousAdult
Base Sequence
Case-Control Studies
Codon
DNA, Single-Stranded
Female
Humans
Molecular Sequence Data
Odds Ratio
Polymorphism, Genetic
Pregnancy
Receptors, Estrogen
Risk Factors